11/10/1995 · Researchers investigating toxic reactions that killed two patients in a trial of interleukin-12 earlier this year have reached a surprising conclusion: The drug is highly toxic if it is given in multiple high doses, but those effects can be avoided if the multiple doses are preceded by a single dose followed by a rest period. The initial dose apparently imprints a memory on.
IL-12 Deaths: Explanation anda Puzzle Researchers testing a promising new drug called interleukin-12 (IL-12) were stunned last June whenseveral patients suffered se-veretoxiceffects…
12/1/1995 · Europe PMC is an ELIXIR Core Data Resource Learn more >. Europe PMC is a service of the Europe PMC Funders’ Group, in partnership with the European Bioinformatics Institute and in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine (NCBI/NLM).It includes content provided to the PMC International.
11/1/1995 · adshelp[at]cfa.harvard.edu The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement NNX16AC86A, Cohen J. IL-12 deaths: explanation and a puzzle . Science. 1995 270:908. 10. Furukawa H, Yabe T, Watanabe K, Miyamoto R, Miki A, Akaza T, et al. Tolerance of NK and LAK activity for HLA class I-deficient targets in a TAP1-deficient patient (bare lymphocyte syndrome type I) Human Immunology. 1999 60 …
9/24/2016 · Cohen J (1995) IL-12 deaths: explanation and a puzzle . Science 270(5238):908 PubMed CrossRef Google Scholar Cohen CA, Shea AA, Heffron CL, Schmelz EM, Roberts PC (2016) Interleukin-12 immunomodulation delays the.
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1/1/1999 · Recombinant human IL-12 (rhIL-12) is currently in clinical trials for treatment of cancer, asthma, and viral hepatitis. Principally a phagocyte-derived cytokine, IL-12 targets natural killer cells and T lymphocytes, stimulating their activity and the secretion of interferon (IFN)-?.
Cohen J. IL-12 deaths: explanation and a puzzle . Science. 1995270(5238):908. [PubMed: 7481785]. 33. Qin Z, Schwartzkopff J, Pradera F, Kammertoens T, Seliger B, Pircher H, et al. A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells.
